Cardiac Pharmacology: Difference between revisions

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!Dose
!Dose
|Amount of active drug given to patient
|Amount of active drug given to patient
|mg (D)
|align="center"|mg (D)
|Drug Specific (From clinical studies)
|Drug Specific (From clinical studies)
|-
|-
!Concentration
!Concentration
|Amount of drug in a given plasma volume
|Amount of drug in a given plasma volume
|µg/ml (C)
|align="center"|µg/ml (C)
|= D / Vd
|align="center"|= D / Vd
|-
|-
!EC<sub>50</sub>
!EC<sub>50</sub>
|The concentration of drug needed to elicit a response halfway between zero and maximal responses.
|The concentration of drug needed to elicit a response halfway between zero and maximal responses.
|µg/ml (EC<sub>50</sub>)
|align="center"|µg/ml (EC<sub>50</sub>)
|align="center"|y = bottom + (Top-Bottom)/(1+ [x/EC50] Hill Coefficient)
|align="center"|y = bottom + (Top-Bottom)/(1+ [x/EC50] Hill Coefficient)
|-
|-
!Volume of Distribution
!Volume of Distribution
|The theoretical volume the drug would occupy if distributed uniformly throughout the tissues to elicit the current plasma concentration.
|The theoretical volume the drug would occupy if distributed uniformly throughout the tissues to elicit the current plasma concentration.
|L (Vd)
|align="center"|L (Vd)
|D / C
|align="center"|D / C
|-
|-
!Elimination Constant (Rate)
!Elimination Constant (Rate)
|The rate at which the drug is removed from the body.
|The rate at which the drug is removed from the body.
|h-1 (Ke)
|align="center"|h-1 (Ke)
|ln(2) / t1/2  or  CL / Vd
|align="center"|ln(2) / t1/2  or  CL / Vd
|-
|-
!Bioavailability
!Bioavailability
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!Cmax or Cmin
!Cmax or Cmin
|The maximum (Cmax) /  minimum (Cmin) plasma drug concentration reached following drug administration
|The maximum (Cmax) /  minimum (Cmin) plasma drug concentration reached following drug administration
|µg/ml (Cmax or Cmin)
|align="center"|µg/ml (Cmax or Cmin)
|Identified via direct measurement of plasma C
|Identified via direct measurement of plasma C
|-
|-
!tmax
!tmax
|The time it takes for a drug to reach Cmax following administration
|The time it takes for a drug to reach Cmax following administration
|h (tmax)
|align="center"|h (tmax)
|Identified via direct measurement of plasma C over time
|Identified via direct measurement of plasma C over time
|-
|-
!Half-life
!Half-life
|The time it takes for a drug to reach half its original concentration
|The time it takes for a drug to reach half its original concentration
|h (t1/2)
|align="center"|h (t1/2)
|ln(2) / Ke
|align="center"|ln(2) / Ke
|-
|-
!Drug Clearance
!Drug Clearance
|The volume of plasma cleared of the drug over a set time
|The volume of plasma cleared of the drug over a set time
|l/h (CL)
|align="center"|l/h (CL)
|Vd x Ke  or  D / Area under curve
|align="center"|Vd x Ke  or  D / Area under curve
|}
|}


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