Cardiac Pharmacology: Difference between revisions

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|ACE Inhibitors
|ACE Inhibitors
|Captopril
|Captopril, monopril
Monopril
|Hypertension
|Hypertension
|Captopril: 12.5mg twice daily
|Captopril: 12.5mg twice daily
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|Angiotensin Receptor Blockers
|Angiotensin Receptor Blockers
|Losartan. Candesartan
|Losartan, candesartan
|Hypertension
|Hypertension
|Losartan: 50mg once daily
|Losartan: 50mg once daily
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|Left ventricular hypertrophy
|Left ventricular hypertrophy
|Losartan: 12.5-150mg daily
|Losartan: 12.5-150mg daily<cite>Esc10</cite>
|ESC Guidelines (European Heart Journal (2012) 33, 2569–2619
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doi:10.1093/eurheartj/ehs215):
LVH:  Class IB
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|Angina
|Angina
|Atenolol: 100mg once/twice daily
|Atenolol: 100mg once/twice daily<cite>Esc11</cite><cite>Esc12</cite>
|ESC and EASD Guidelines (European Heart Journal doi: 10.1093/eurheart/ehl261)
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ACS: Class IIaB
 
ESC Guidelines (European Heart Journal
doi:10.1093/eurheartj/ehs104):
Angina in symptomatic (NYHA class II-IV) HF and LVD: Class IA
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|Arrhythmias
|Arrhythmias
|Atenolol: 50-100mg daily
|Atenolol: 50-100mg daily<cite>Esc13</cite><cite>Esc14</cite><cite>Acc15</cite>
|ESC Guidelines (European Heart Journal (2012) 33, 2569–2619
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doi:10.1093/eurheartj/ehs215):
 
Atrial fibrillation: Class IA
Polymorphic VT: Class IB
 
ESC Guidelines (European Heart Journal
doi:10.1093/eurheartj/ehs104):
Symptomatic (NYHA class II-IV) HF, LVD and AF: Class IA
Management of VA in HF: Class IA
 
ACC/AHA/ESC Guidelines (Blomström-Lundqvist and Scheinman et al. 2003):
SVT: Class IIbC
Wide QRS-complex tachycardia of unknown origin: Class IIIC
Sinus tachycardia: Class IC
Poorly tolerated AVNRT with haemodynamic intolerance: Class IIaC
Recurrent symptomatic AVNRT: Class IC
Documented PSVT with only dual AV-nodal pathways or single echo beats demonstrated during electrophysiological study and no other identified cause of arrhythmia: Class IC
Infrequent, well tolerated AVNRT: Class IB
Focal junction tachycardia: Class IIaC
Nonparoxysmal junctional tachycardia: Class IIaC
WPW Syndrome: Class IIaC
AVRT, poorly tolerated: Class IIbC
Since or infrequent AVRT episode(s): Class IIaB
Acute treatment of Focal Atrial Tachycardia: Class IIaC
Prophylactic therapy for AT: Class IC
AF (Poorly tolerated): Class IIaC
AF (Stable flutter): Class IC
Prophylaxis of SVT during pregnancy: Class IIaB
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|Hypertension
|Hypertension
|Nifedipine: 20-30mg once daily
|Nifedipine: 20-30mg once daily
|ESC Guidelines (European Heart Journal
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doi:10.1093/eurheartj/ehs104):
|Gastro-intestinal disturbance (2-11%); hypotension (1-5%), oedema (7-29%), vasodilatation, palpitation; headache (7-35%), dizziness (3-27%), lethargy (4-6%), asthenia (10-12%); less commonly tachycardia (<1-7%), syncope (<1%), chills, nasal congestion, dyspnoea (<3%), anxiety, sleep disturbance (<2%), vertigo (<3%), migraine, paraesthesia, tremor (1-8%), polyuria, dysuria, nocturia, erectile dysfunction (<2%), epistaxis, myalgia, joint swelling, visual disturbance (<2%), sweating (<2%), hypersensitivity reactions (<1%); rarely anorexia, gum hyperplasia, mood disturbances, hyperglycaemia, male infertility, purpura (<1%), and photosensitivity reactions (<1%); also reported dysphagia, intestinal obstruction, intestinal ulcer, bezoar formation, gynaecomastia, agranulocytosis, and anaphylaxis;<cite>Esc16</cite>
Hypertension in symptomatic (NYHA class II-IV) HF and LVD: Class IA
|gastro-intestinal disturbance (2-11%); hypotension (1-5%), oedema (7-29%), vasodilatation, palpitation; headache (7-35%), dizziness (3-27%), lethargy (4-6%), asthenia (10-12%); less commonly tachycardia (<1-7%), syncope (<1%), chills, nasal congestion, dyspnoea (<3%), anxiety, sleep disturbance (<2%), vertigo (<3%), migraine, paraesthesia, tremor (1-8%), polyuria, dysuria, nocturia, erectile dysfunction (<2%), epistaxis, myalgia, joint swelling, visual disturbance (<2%), sweating (<2%), hypersensitivity reactions (<1%); rarely anorexia, gum hyperplasia, mood disturbances, hyperglycaemia, male infertility, purpura (<1%), and photosensitivity reactions (<1%); also reported dysphagia, intestinal obstruction, intestinal ulcer, bezoar formation, gynaecomastia, agranulocytosis, and anaphylaxis;
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|Angina (prophylaxis)
|Angina (prophylaxis)
|Nifedipine: 5-20mg 3 times daily
|Nifedipine: 5-20mg 3 times daily<cite>17</cite>
|ESC Guidelines (European Heart Journal
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doi:10.1093/eurheartj/ehs104):
Angina in symptomatic (NYHA class II-IV) HF and LVD: Class IIaA
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#Esc8 ESC and EASD Guidelines (European Heart Journal doi: 10.1093/eurheart/ehl261): Hypertension: Class IA
#Esc8 ESC and EASD Guidelines (European Heart Journal doi: 10.1093/eurheart/ehl261): Hypertension: Class IA
#Esc9 ESC Guidelines: (European Heart Journal doi:10.1093/eurheartj/ehs092): Hypertension in diabetics: Class IA
#Esc9 ESC Guidelines: (European Heart Journal doi:10.1093/eurheartj/ehs092): Hypertension in diabetics: Class IA
#Esc10 ESC Guidelines (European Heart Journal (2012) 33, 2569–2619 doi:10.1093/eurheartj/ehs215): LVH: Class IB
#Esc11 ESC and EASD Guidelines (European Heart Journal doi: 10.1093/eurheart/ehl261) ACS: Class IIaB
#Esc12 ESC Guidelines (European Heart Journal doi:10.1093/eurheartj/ehs104): Angina in symptomatic (NYHA class II-IV) HF and LVD: Class IA
#Esc13 ESC Guidelines (European Heart Journal (2012) 33, 2569–2619 doi:10.1093/eurheartj/ehs215): Atrial fibrillation: Class IA; Polymorphic VT: Class IB
#Esc14 ESC Guidelines (European Heart Journal doi:10.1093/eurheartj/ehs104): Symptomatic (NYHA class II-IV) HF, LVD and AF: Class IA; Management of VA in HF: Class IA
#Acc15 ACC/AHA/ESC Guidelines (Blomström-Lundqvist and Scheinman et al. 2003): SVT: Class IIbC; Wide QRS-complex tachycardia of unknown origin: Class IIIC; Sinus tachycardia: Class IC; Poorly tolerated AVNRT with haemodynamic intolerance: Class IIaC; Recurrent symptomatic AVNRT: Class IC; Documented PSVT with only dual AV-nodal pathways or single echo beats demonstrated during electrophysiological study and no other identified cause of arrhythmia: Class IC; Infrequent, well tolerated AVNRT: Class IB; Focal junction tachycardia: Class IIaC; Nonparoxysmal junctional tachycardia: Class IIaC; WPW Syndrome: Class IIaC; AVRT, poorly tolerated: Class IIbC; Since or infrequent AVRT episode(s): Class IIaB; Acute treatment of Focal Atrial Tachycardia: Class IIaC; Prophylactic therapy for AT: Class IC; AF (Poorly tolerated): Class IIaC; AF (Stable flutter): Class IC; Prophylaxis of SVT during pregnancy: Class IIaB
#Esc16 ESC Guidelines (European Heart Journal doi:10.1093/eurheartj/ehs104): Hypertension in symptomatic (NYHA class II-IV) HF and LVD: Class IA
#Esc17 ESC Guidelines (European Heart Journal doi:10.1093/eurheartj/ehs104): Angina in symptomatic (NYHA class II-IV) HF and LVD: Class IIaA




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