Brugada Syndrome: Difference between revisions
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[[Image:scn5a.jpg|thumb|right|The SCN5a gen is located on the short arm (p) of chromosome 3]] | [[Image:scn5a.jpg|thumb|right|The SCN5a gen is located on the short arm (p) of chromosome 3]] | ||
'''Brugada syndrome''' refers to a hereditary disease that is associated with a risk of sudden cardiac death. It is characterized by typical ECG abnormalities: ST segment elevation in the precordial leads (V1 - V3). | |||
The Brugada brothers were the first to describe the characteristic ECG findings and link them to sudden death. Before that, the characteristic ECG findings, were often mistaken for a right ventricle myocardial infarction and already in 1953, a publication mentions that the ECG findings were not associated with ischemia as people often expected. | |||
* | ==General features== | ||
*Males are more | *The diagnosis is based on ECG findings. | ||
*The arrhythmias | *It is an inheritable cardiac arrhythmia syndrome with an autosomal dominant inheritance. | ||
*Males are often more symptomatic than females, probably by the influence of sex hormones on cardiac arrhythmias and/or ion channels. | |||
*The right ventricle is most affected in Brugada syndrome, and particularly (but not specifically) the right ventricular outflow tract . | *The arrhythmias typically occur in patients between 30-40 years of age and often during rest or while sleeping. | ||
*The prevalence varies between 5-50:10.000, largely depending on geographic location | *The right ventricle is most affected in Brugada syndrome, and particularly (but not specifically) the right ventricular outflow tract. | ||
*The prevalence varies between 5-50:10.000, largely depending on the geographic location (especially in some Southeast Asian countries the disease is more prevalent). | |||
== | ==Clinical diagnosis== | ||
The clinical diagnosis of Brugada syndrome is confirmed in an individual with the following: | |||
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