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===Physical examination=== | ===Physical examination=== | ||
[[Image: | [[Image:Torsade_de_Pointes.png|500px|right|thumb]] | ||
Patients can present with symptoms of arrhythmias: | Patients can present with symptoms of arrhythmias: | ||
*Fast or slow heart beat | *Fast or slow heart beat | ||
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|'''Eponyme''' | |'''Eponyme''' | ||
|If condition is homozygous: Jervell and Lange-Nielsen syndrome 1 | |If condition is homozygous: Jervell and Lange-Nielsen syndrome 1 | ||
| | |||
| | | | ||
|} | |} | ||
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450-459 (in males) | 450-459 (in males) | ||
>480 during | >480 during X-ECG | ||
X-ECG | |||
|valign="top"|3 | |valign="top"|3 | ||
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|0.5 | |0.5 | ||
|- | |- | ||
|colspan="4"|''Total score | |colspan="4"|''Total score ≤1 Low probability; 1.5-3 Intermediate probability; ≥3.5 High probability'' | ||
|} | |} | ||
Diagnostic criteria by Schwartz et al. (2011)<cite>Schwartz2001</cite> | |||
==Clinical diagnosis== | ==Clinical diagnosis== | ||
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===Medication/Other therapies:=== | ===Medication/Other therapies:=== | ||
*Beta-blockers are the cornerstone of therapy in LQTS. Beta-blockers even reduce the risk of sudden death in patients in whom a genetic defect has been found, but no QT | *Beta-blockers are the cornerstone of therapy in LQTS. Beta-blockers even reduce the risk of sudden death in patients in whom a genetic defect has been found, but no QT prolon | ||
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<biblio> | <biblio> | ||
#Schwartz2001 pmid=11136691 | #Schwartz2001 pmid=11136691 | ||
#Alders pmid=20301308 | |||
#adenosine pmid=16105845 | |||
#priori pmid=12736279 | #priori pmid=12736279 | ||
#Adler pmid=22300664 | #Adler pmid=22300664 | ||
# | #Shimizu2009 pmid=19926013 | ||
# | #Moss pmid=17470695 | ||
#Sy pmid=22042885 | |||
#Schwartz2011 pmid=22083145 | |||
#Viskin pmid=20116193 | |||
#Shimizu2004 pmid=15851169 | |||
</biblio> | </biblio> |