ICD Primary prevention trials

From Textbook of Cardiology
Revision as of 11:52, 15 January 2012 by Secretariat (talk | contribs)
Jump to navigation Jump to search

placeholder

Study Inclusion Criteria Number Randomized Control Group Primary Point Main Finding
MADIT I35 Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III 196 Conventional therapy All-cause mortality 54% RRR in all-cause

mortality with ICD (P=0.009); absolute RR 23%

CABG-PATCH36 EF <35%, abnormal SAECG, elective CABG 900 Conventional therapy All-cause mortality No difference in all-cause mortality
MUSTT37 Prior MI, EF ≤40%, NSVT, inducible VT on EPS 704 EP-guided antiarrhythmic therapy or conventional therapy Cardiac arrest or death due to arrhythmia 60% RRR in all-cause mortality with ICD (P=0.001); absolute RR 31%
MADIT II39 Prior MI≤1 month, EF≤30%, NYHA class I–III 1232 Conventional therapy All-cause mortality 31% RRR in all-cause mortality with ICD (P=0.016); absolute RR 6%
DINAMIT38 Recent (6–40 days) MI, EF≤35%, abnormal HRV or elevated average HR on 24-h Holter, NYHA class I–III 674 Conventional therapy All-cause mortality No difference in all-cause mortality; 58% RRR from arrhythmia with ICD (P=0.009)
SCD-HeFT34 EF≤35%, (ischemic or nonischemic) NYHA class II–III 2521 Conventional therapy±amiodarone All-cause mortality 23% RRR in all-cause mortality with ICD (P=0.007); absolute RR 7%
EF indicates ejection fraction; NSVT, nonsustained VT; EPS, electrophysiological study; NYHA, New York Heart Association; RRR, relative risk reduction; RR, risk reduction; CABG, coronary artery bypass grafting; SAECG, signal-averaged ECG; HRV, heart rate variability; and HR, heart rate.