ICD Primary prevention trials: Difference between revisions

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| MADIT I<sup>35</sup>
| MADIT I<sup>35</sup>
| Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III
| Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III
| 196
| align="center" | 196
| Conventional therapy
| Conventional therapy
| All-cause mortality
| All-cause mortality
Line 20: Line 20:
| CABG-PATCH<sup>36</sup>
| CABG-PATCH<sup>36</sup>
| EF <35%, abnormal SAECG, elective CABG
| EF <35%, abnormal SAECG, elective CABG
| 900
| align="center" | 900
| Conventional therapy  
| Conventional therapy  
| All-cause mortality
| All-cause mortality
Line 28: Line 28:
| MUSTT<sup>37</sup>
| MUSTT<sup>37</sup>
| Prior MI, EF ≤40%, NSVT, inducible VT on EPS
| Prior MI, EF ≤40%, NSVT, inducible VT on EPS
| 704  
| align="center" | 704  
| EP-guided antiarrhythmic therapy or conventional therapy
| EP-guided antiarrhythmic therapy or conventional therapy
| Cardiac arrest or death due to arrhythmia
| Cardiac arrest or death due to arrhythmia
| 60% RRR in all-cause mortality with ICD (''P''=0.001); absolute RR 31%
| 60% RRR in all-cause mortality with ICD (''P''=0.001); absolute RR 31%
|-
| MADIT II<sup>39</sup>
| Prior MI≤1 month, EF≤30%, NYHA class I–III
| align="center" | 1232
| Conventional therapy
| All-cause mortality
| 31% RRR in all-cause mortality with ICD (''P''=0.016); absolute RR 6%
|-
| DINAMIT<sup>38</sup>
| Recent (6–40 days) MI, EF≤35%, abnormal HRV or elevated average HR on 24-h Holter, NYHA class I–III
| align="center" | 674
| Conventional therapy
| All-cause mortality
| No difference in all-cause mortality; 58% RRR from arrhythmia with ICD (''P''=0.009)
|-
| SCD-HeFT<sup>34</sup>
| EF≤35%, (ischemic or nonischemic) NYHA class II–III
| align="center" | 2521
| Conventional therapy±amiodarone
| All-cause mortality
| 23% RRR in all-cause mortality with ICD (''P''=0.007); absolute RR 7%
|}
|}
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