ICD Primary prevention trials: Difference between revisions
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| Line 12: | Line 12: | ||
| MADIT I<sup>35</sup> | | MADIT I<sup>35</sup> | ||
| Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III | | Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III | ||
| 196 | | align="center" | 196 | ||
| Conventional therapy | | Conventional therapy | ||
| All-cause mortality | | All-cause mortality | ||
| Line 20: | Line 20: | ||
| CABG-PATCH<sup>36</sup> | | CABG-PATCH<sup>36</sup> | ||
| EF <35%, abnormal SAECG, elective CABG | | EF <35%, abnormal SAECG, elective CABG | ||
| 900 | | align="center" | 900 | ||
| Conventional therapy | | Conventional therapy | ||
| All-cause mortality | | All-cause mortality | ||
| Line 28: | Line 28: | ||
| MUSTT<sup>37</sup> | | MUSTT<sup>37</sup> | ||
| Prior MI, EF ≤40%, NSVT, inducible VT on EPS | | Prior MI, EF ≤40%, NSVT, inducible VT on EPS | ||
| 704 | | align="center" | 704 | ||
| EP-guided antiarrhythmic therapy or conventional therapy | | EP-guided antiarrhythmic therapy or conventional therapy | ||
| Cardiac arrest or death due to arrhythmia | | Cardiac arrest or death due to arrhythmia | ||
| 60% RRR in all-cause mortality with ICD (''P''=0.001); absolute RR 31% | | 60% RRR in all-cause mortality with ICD (''P''=0.001); absolute RR 31% | ||
|- | |||
| MADIT II<sup>39</sup> | |||
| Prior MI≤1 month, EF≤30%, NYHA class I–III | |||
| align="center" | 1232 | |||
| Conventional therapy | |||
| All-cause mortality | |||
| 31% RRR in all-cause mortality with ICD (''P''=0.016); absolute RR 6% | |||
|- | |||
| DINAMIT<sup>38</sup> | |||
| Recent (6–40 days) MI, EF≤35%, abnormal HRV or elevated average HR on 24-h Holter, NYHA class I–III | |||
| align="center" | 674 | |||
| Conventional therapy | |||
| All-cause mortality | |||
| No difference in all-cause mortality; 58% RRR from arrhythmia with ICD (''P''=0.009) | |||
|- | |||
| SCD-HeFT<sup>34</sup> | |||
| EF≤35%, (ischemic or nonischemic) NYHA class II–III | |||
| align="center" | 2521 | |||
| Conventional therapy±amiodarone | |||
| All-cause mortality | |||
| 23% RRR in all-cause mortality with ICD (''P''=0.007); absolute RR 7% | |||
|} | |} | ||
Revision as of 11:51, 15 January 2012
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| Study | Inclusion Criteria | Number Randomized | Control Group | Primary Point | Main Finding |
|---|---|---|---|---|---|
| MADIT I35 | Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III | 196 | Conventional therapy | All-cause mortality | 54% RRR in all-cause
mortality with ICD (P=0.009); absolute RR 23% |
| CABG-PATCH36 | EF <35%, abnormal SAECG, elective CABG | 900 | Conventional therapy | All-cause mortality | No difference in all-cause mortality |
| MUSTT37 | Prior MI, EF ≤40%, NSVT, inducible VT on EPS | 704 | EP-guided antiarrhythmic therapy or conventional therapy | Cardiac arrest or death due to arrhythmia | 60% RRR in all-cause mortality with ICD (P=0.001); absolute RR 31% |
| MADIT II39 | Prior MI≤1 month, EF≤30%, NYHA class I–III | 1232 | Conventional therapy | All-cause mortality | 31% RRR in all-cause mortality with ICD (P=0.016); absolute RR 6% |
| DINAMIT38 | Recent (6–40 days) MI, EF≤35%, abnormal HRV or elevated average HR on 24-h Holter, NYHA class I–III | 674 | Conventional therapy | All-cause mortality | No difference in all-cause mortality; 58% RRR from arrhythmia with ICD (P=0.009) |
| SCD-HeFT34 | EF≤35%, (ischemic or nonischemic) NYHA class II–III | 2521 | Conventional therapy±amiodarone | All-cause mortality | 23% RRR in all-cause mortality with ICD (P=0.007); absolute RR 7% |