Diagnostic Testing: Difference between revisions

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==Electrocardiography (ECG)==
==Electrocardiography (ECG)==
[[Image:Nsr.png|300px|thumb|Figure 1. A short ECG registration of the normal heart rhythm (sinus rhythm). Source:http://en.ecgpedia.org/wiki/File:Nsr.png]]
[[Image:Nsr.png|400px|thumb|'''Figure 1.''' A short ECG registration of the normal heart rhythm (sinus rhythm). Source:http://en.ecgpedia.org/wiki/File:Nsr.png]]


The electrocardiogram asses the electrical activity of the human heart and translates this into a graphic representation. In Figure 1 the body location for the 10 electrodes of a 12-channel ECG are shown. The exact placement of the electrodes is of utmost importance in obtaining an interpretable ECG. The ECG is a graphic representation of the difference in voltage between the patches over time.  
The electrocardiogram asses the electrical activity of the human heart and translates this into a graphic representation. In ''Figure 1'' the body location for the 10 electrodes of a 12-channel ECG are shown. The exact placement of the electrodes is of utmost importance in obtaining an interpretable ECG. The ECG is a graphic representation of the difference in voltage between the patches over time.  
   
   
An ECG can be used to directly clarify the mechanism of an irregular heart rhythm detected on physical examination or that of an extremely rapid or slow rhythm. In addition the ECG can help in identifying structural heart disease (i.e. cardiac hypertrophy), ischemic heart disease (i.e. myocardial infarction) or other causes of symptoms outside of the heart (i.e. pulmonary embolism). So called Holter monitoring or other continuous-ECG monitoring devices allow assessment of cardiac rate and rhythm on a continuous and ambulatory basis. The most common use of ECG monitoring is the evaluation of symptoms such as syncope, near-syncope, or palpitation for which there is no obvious cause and cardiac rhythm disturbances are suspected.
An ECG can be used to directly clarify the mechanism of an irregular heart rhythm detected on physical examination or that of an extremely rapid or slow rhythm. In addition the ECG can help in identifying structural heart disease (i.e. cardiac hypertrophy), ischemic heart disease (i.e. myocardial infarction) or other causes of symptoms outside of the heart (i.e. pulmonary embolism). So called Holter monitoring or other continuous-ECG monitoring devices allow assessment of cardiac rate and rhythm on a continuous and ambulatory basis. The most common use of ECG monitoring is the evaluation of symptoms such as syncope, near-syncope, or palpitation for which there is no obvious cause and cardiac rhythm disturbances are suspected.
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Another example of the helpful use of the ECG is the characteristic changes on the ECG associated with ventricular or atrial enlargement, which could strengthen the diagnosis of cardiomyopathic or valvular disease based on the physical examination.  
Another example of the helpful use of the ECG is the characteristic changes on the ECG associated with ventricular or atrial enlargement, which could strengthen the diagnosis of cardiomyopathic or valvular disease based on the physical examination.  
Lastly, evidence of conduction abnormalities may help explain the mechanism of arrhythmias causing symptoms such as palpitations, syncope or angina
Lastly, evidence of conduction abnormalities may help explain the mechanism of arrhythmias causing symptoms such as palpitations, syncope or angina


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#Conclusion
#Conclusion
   
   
[[Image:QRSwaves.jpg|300px|thumb|Figure 2.
A representation of the several intervals of an ECG.
Source:http://en.ecgpedia.org/wiki/File:QRSwaves.jpg ]]
===Rhythm===
===Rhythm===
The sinus node (SA) is located in the roof of the right atrium. It is the fastest physiological pacemaker. When the sinus node generates an electrical impulse, the surrounding cells of the right atrium depolarize. Then the cells of the left atrium, the AV (atrioventricular)node, follow, and at last the ventricles are stimulated via the His bundle. The presence and assessment of P-wave morphology is necessary to determine the rhythm. Normal sinus node rhythm can be presumed if the following criteria are met:
The sinus node (SA) is located in the roof of the right atrium. It is the fastest physiological pacemaker. When the sinus node generates an electrical impulse, the surrounding cells of the right atrium depolarize. Then the cells of the left atrium, the AV (atrioventricular)node, follow, and at last the ventricles are stimulated via the His bundle. The presence and assessment of P-wave morphology is necessary to determine the rhythm. Normal sinus node rhythm can be presumed if the following criteria are met:
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===Conduction===
===Conduction===
[[Image:QRSwaves.jpg|300px|thumb|'''Figure 2.''' A representation of the several intervals of an ECG.
Source:http://en.ecgpedia.org/wiki/File:QRSwaves.jpg ]]
====PQ interval====
====PQ interval====
The PQ interval starts at the beginning of the atrial contraction and ends at the beginning of the ventricular contraction.
The PQ interval starts at the beginning of the atrial contraction and ends at the beginning of the ventricular contraction.
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*Negative (or inverted) T wave
*Negative (or inverted) T wave


A broad spectrum of disease could cause ST segment abnormalities such as (acute) ischemia (ST segment elevation and/or depression and T wave inversion), pulmonary embolism (ST segment elevation), acute neurologic events (ST segment elevation), and pericarditis (ST segment elevation). For a complete list see [http://en.ecgpedia.org/wiki/ST_Morphology ST_Morphology]
A broad spectrum of disease could cause ST segment abnormalities such as (acute) ischemia (ST segment elevation and/or depression and T wave inversion), pulmonary embolism (ST segment elevation), acute neurologic events (ST segment elevation), and pericarditis (ST segment elevation). For a complete list see [http://en.ecgpedia.org/wiki/ST_Morphology ST Morphology]


'''Compare the old and the new ECG'''
'''Compare the old and the new ECG'''
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==Echocardiography==
==Echocardiography==
Echocardiography is based on the use of ultrasound directed at the heart to create images of cardiac anatomy and display them in real time on a digital screen. The transthoracic echocardiography is obtained by placing a transducer in various positions on the anterior chest The processing of the ultrasound waves creates cross-sectional images of the heart and great vessels in a variety of standard planes. In general, echocardiography is a sensitive and non-invasive tool for detecting anatomic abnormalities of the heart and great vessels. [Figure 3]
Echocardiography is based on the use of ultrasound directed at the heart to create images of cardiac anatomy and display them in real time on a digital screen. The transthoracic echocardiography is obtained by placing a transducer in various positions on the anterior chest The processing of the ultrasound waves creates cross-sectional images of the heart and great vessels in a variety of standard planes. In general, echocardiography is a sensitive and non-invasive tool for detecting anatomic abnormalities of the heart and great vessels. nbsp;nbsp;[''Figure 3'']
 
{| class="wikitable" cellpadding="0" cellspacing="0" border="0" width="100%"
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|align="center" bgcolor="#FFFFFF"|[[Image:Heart_lpla_echocardiography_diagram.jpg|400px]]
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|align="center"|'''Figure 3.''' Transthoracic echocardiography.
 
Source: http://commons.wikimedia.org/wiki/File%3AHeart_lpla_echocardiography_diagram.jpg
|}
 
The two-dimensional echocardiographic imaging technique is used to investigate the heart in multiple planes in order to asses the existence of (dys)function and structural abnormalities of cardiac chambers and valves throughout the cardiac cycle. Both the cross sectional and longitudinal views are used to look for the presence of any anatomical or functional abnormalities with most of the structures of the heart. [''Figure 4 & 5'']
 
{| class="wikitable" cellpadding="0" cellspacing="0" border="0" width="100%"
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|align="center" bgcolor="#FFFFFF"|[[Image:Apical_4_chamber_view.gif|400px]]
|align="center" bgcolor="#FFFFFF"|[[Image:LeftVentricleShortAxis.gif|400px]]
|-
|align="center"|'''Figure 4.''' Apical four chamber view by two dimensional echocardiography.
 
Source: http://commons.wikimedia.org/wiki/File%3AApical_4_chamber_view.gif
|align="center"|'''Figure 5.''' Short axis view of left ventricle by two dimensional echocardiography.
 
Source: http://commons.wikimedia.org/wiki/File%3ALeftVentricleShortAxis.gif
|}
 
In addition, in the cross sectional planes ventricular wall motion and left ventricular wall thickening during systole (an important measure of myocardial viability) can be investigated. The systematically assessment of cross sectional segment can also be used to estimate left ventricular volumes and ejection fraction. [''Figure 6'']
   
   
[[Image:Heart_lpla_echocardiography_diagram.jpg|thumb|300px|Figure 3. Transthoracic echocardiography. Source: http://commons.wikimedia.org/wiki/File%3AHeart_lpla_echocardiography_diagram.jpg]]
{| class="wikitable" cellpadding="0" cellspacing="0" border="0" width="100%"
|-
|align="center" bgcolor="#FFFFFF"|[[Image:Heart_short_axis_myocardial_segments.svg|400px]]
|-
|align="center"|'''Figure 6.''' Heart short axis with myocardial segments.  


The two-dimensional echocardiographic imaging technique is used to investigate the heart in multiple planes in order to asses the existence of (dys)function and structural abnormalities of cardiac chambers and valves throughout the cardiac cycle. Both the cross sectional and longitudinal views are used to look for the presence of any anatomical or functional abnormalities with most of the structures of the heart. [Figure 4&5]
Source: http://commons.wikimedia.org/wiki/File%3AHeart_short_axis_myocardial_segments.svg
|}
[[Image:Apical_4_chamber_view.gif|thumb|300px|Figure 4. Apical four chamber view by two dimensional echocardiography. Source: http://commons.wikimedia.org/wiki/File%3AApical_4_chamber_view.gif]]
 
Although the two-dimensional imaging technique gives superior view of the important structures of the heart, the analog echocardiographic display referred to as M-mode, motion-mode, or time-motion mode, is still in use for the high resolution axial and temporal imaging. The analog technique is preferred to measure the size of structures in its axial direction, and its high sampling rate allows for the resolution of complex cardiac motion patterns. [''Figure 7'']
[[Image:LeftVentricleShortAxis.gif|thumb|300px|Figure 5. Short axis view of left ventricle by two dimensional echocardiography. Source: http://commons.wikimedia.org/wiki/File%3ALeftVentricleShortAxis.gif]]
 
{| class="wikitable" cellpadding="0" cellspacing="0" border="0" width="100%"
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|align="center" bgcolor="#FFFFFF"|[[Image:PLAX_Mmode.jpg|400px]]
|-
|align="center"|'''Figure 7.''' Echocardiogram in the parasternal long-axis view, showing a measurement of the heart's left ventricle in M-mode.  


In addition, in the cross sectional planes ventricular wall motion and left ventricular wall thickening during systole (an important measure of myocardial viability) can be investigated. The systematically assessment of cross sectional segment can also be used to estimate left ventricular volumes and ejection fraction. [Figure 6]
Source:http://commons.wikimedia.org/wiki/File:PLAX_Mmode.jpg]]
|}
[[Image:Heart_short_axis_myocardial_segments.svg|thumb|300px|Figure 6. Heart short axis with myocardial segments. Source: http://commons.wikimedia.org/wiki/File%3AHeart_short_axis_myocardial_segments.svg]]


Although the two-dimensional imaging technique gives superior view of the important structures of the heart, the analog echocardiographic display referred to as M-mode, motion-mode, or time-motion mode, is still in use for the high resolution axial and temporal imaging. The analog technique is preferred to measure the size of structures in its axial direction, and its high sampling rate allows for the resolution of complex cardiac motion patterns. [Figure 7]
Doppler ultrasound is a technique of combined with the traditional ultrasound technique. The Doppler technique assesses changes in frequency of the reflected ultrasound compared with the transmitted ultrasound. The difference is used to be translated in a picture of the flow velocity. The continuous-wave Doppler mode is used to quantitate the exact velocity of the flow and estimate the pressure gradient when high velocities are suspected. The technique creates a graphic representation of the flow velocity in echotransducers’ beam in a time continuous wave. The technique is hampered by the fact that anatomical structures can make disturb the beam and subsequently the flow velocity measurement. When there is ambiguity about the source of the high velocity, pulsed-wave Doppler could be a more useful tool. This technique is range-gated in order to make it possible to investigate specific areas along the beam (sample volumes).  Another technique widely integrated in echocardiography is the colour Doppler. The colour Doppler technique projects in coloured images informative for the direction of flow, the velocity, and the presence or absence of turbulent flow. The flow velocity colour images are in real-time combined with the two-dimensional structural imaging to investigate blood flow in the heart and great vessels. The colour Doppler image technique is in particular of use in detecting regurgitant blood flows across cardiac valves or to visualise any abnormal communications in the heart. [''Figure 8'']
   
   
[[Image:PLAX_Mmode.jpg|thumb|300px|Figure 7. Echocardiogram in the parasternal long-axis view, showing a measurement of the heart's left ventricle in M-mode. Source:http://commons.wikimedia.org/wiki/File:PLAX_Mmode.jpg]]
{| class="wikitable" cellpadding="0" cellspacing="0" border="0" width="100%"
|-
|align="center" bgcolor="#FFFFFF"|[[Image:Ventricular_Septal_Defect.jpg|400px]]
|-
|align="center"|'''Figure 8.''' Apical view with colour Doppler projection showing a ventricular septal defect.  


Doppler ultrasound is a technique of combined with the traditional ultrasound technique. The Doppler technique assesses changes in frequency of the reflected ultrasound compared with the transmitted ultrasound. The difference is used to be translated in a picture of the flow velocity. The continuous-wave Doppler mode is used to quantitate the exact velocity of the flow and estimate the pressure gradient when high velocities are suspected. The technique creates a graphic representation of the flow velocity in echotransducers’ beam in a time continuous wave. The technique is hampered by the fact that anatomical structures can make disturb the beam and subsequently the flow velocity measurement. When there is ambiguity about the source of the high velocity, pulsed-wave Doppler could be a more useful tool. This technique is range-gated in order to make it possible to investigate specific areas along the beam (sample volumes).  Another technique widely integrated in echocardiography is the colour Doppler. The colour Doppler technique projects in coloured images informative for the direction of flow, the velocity, and the presence or absence of turbulent flow. The flow velocity colour images are in real-time combined with the two-dimensional structural imaging to investigate blood flow in the heart and great vessels. The colour Doppler image technique is in particular of use in detecting regurgitant blood flows across cardiac valves or to visualise any abnormal communications in the heart. [Figure 8]
Source:http://commons.wikimedia.org/wiki/File:Ventricular_Septal_Defect.jpg]]
|}
[[Image:Ventricular_Septal_Defect.jpg|thumb|300px|Figure 8. Apical view with colour Doppler projection showing a ventricular septal defect. Source:http://commons.wikimedia.org/wiki/File:Ventricular_Septal_Defect.jpg]]


The non-invasive echocardiography has now largely replaced cardiac catheterization for calculation of the hemodynamics changes caused by valvular disease. Several examples of methods to examine hemodynamics of the heart and valves by echocardiopgraphy are:
The non-invasive echocardiography has now largely replaced cardiac catheterization for calculation of the hemodynamics changes caused by valvular disease. Several examples of methods to examine hemodynamics of the heart and valves by echocardiopgraphy are:
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*Cardiac output and pressure gradients can be used to calculate the stenotic valve area.
*Cardiac output and pressure gradients can be used to calculate the stenotic valve area.


Unfortunately, it is impossible to obtain high-quality images or Doppler signals in as many a small percent of patients. Underlying conditions such as obesity, emphysema or chest wall deformities can limit the use of transthoracic echocardiography. A technique to partly cope with these limitations is transoesophageal echocardiography (TEE) [figure 9].  
Unfortunately, it is impossible to obtain high-quality images or Doppler signals in as many a small percent of patients. Underlying conditions such as obesity, emphysema or chest wall deformities can limit the use of transthoracic echocardiography. A technique to partly cope with these limitations is transoesophageal echocardiography (TEE) [''Figure 9''].  
   
   
[[Image:Transesophageal echocardiography diagram.svg|thumb|300px|Figure 9. Transoesophageal echocardiography. Source: http://commons.wikimedia.org/wiki/File%3ATransesophageal_echocardiography_diagram.svg]]
{| class="wikitable" cellpadding="0" cellspacing="0" border="0" width="100%"
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|align="center" bgcolor="#FFFFFF"|[[Image:Transesophageal echocardiography diagram.svg|400px]]
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|align="center"|'''Figure 9.''' Transoesophageal echocardiography.  
 
Source: http://commons.wikimedia.org/wiki/File%3ATransesophageal_echocardiography_diagram.svg]]
|}


With TEE a smaller ultrasound probe is placed on a gastroscopic device for introduction in the oesophagus behind the heart. Besides overcoming structural problems, in general TEE produces much higher resolution images of posterior cardiac structures. With TEE left atrial thrombi, small mitral valve vegetations, and thoracic aortic dissection can be diagnosed a high degree of accuracy. The downside of the techniques is the invasiveness of the procedure; the introduction of a probe into the oesophagus is very often experienced as rather uncomfortable by patients.
With TEE a smaller ultrasound probe is placed on a gastroscopic device for introduction in the oesophagus behind the heart. Besides overcoming structural problems, in general TEE produces much higher resolution images of posterior cardiac structures. With TEE left atrial thrombi, small mitral valve vegetations, and thoracic aortic dissection can be diagnosed a high degree of accuracy. The downside of the techniques is the invasiveness of the procedure; the introduction of a probe into the oesophagus is very often experienced as rather uncomfortable by patients.
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==Cardiac stress test==
==Cardiac stress test==
[[Image:Stress_test.jpg|thumb|300px|'''Figure 10.''' Cardiac stress test making use of a walking treadmill. Source:http://commons.wikimedia.org/wiki/File%3AStress_test.jpg]]
Cardiac stress testing is a test used to measure the heart’s ability to respond to external stress in a controlled environment. The stress response of the heart in the test is induced by exercise, such as treadmill walking or biking, or by mimicked by drugs, such as adenosine, dipyridamole or dobutamine. Exercise is the preferred modality for inducing cardiac stress and increasing myocardial oxygen demand. Two main reasons for a pharmalogical induced stress test are; the patient's inability to exercise adequately because of physical or psychologic limitations; or the chosen test does not go along with exercise (i.e., PET scanning). Methods used in stress testing are:
Cardiac stress testing is a test used to measure the heart’s ability to respond to external stress in a controlled environment. The stress response of the heart in the test is induced by exercise, such as treadmill walking or biking, or by mimicked by drugs, such as adenosine, dipyridamole or dobutamine. Exercise is the preferred modality for inducing cardiac stress and increasing myocardial oxygen demand. Two main reasons for a pharmalogical induced stress test are; the patient's inability to exercise adequately because of physical or psychologic limitations; or the chosen test does not go along with exercise (i.e., PET scanning). Methods used in stress testing are:
*Electrocardiography
*Electrocardiography
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*Myocardial resonance imaging
*Myocardial resonance imaging
   
   
[[Image:Stress_test.jpg|thumb|300px|Figure 10. Cardiac stress test making use of a walking treadmill. Source:http://commons.wikimedia.org/wiki/File%3AStress_test.jpg]]
The induced cardiac stress is most widely used to compare the coronary circulation during exercise with the circulation in rest. An imbalance between myocardial oxygen supply and demand due to coronary disease can be revealed as a result of the increased oxygen demand during stress conditions. By this means stress testing can reveal myocardial ischemia during exercise, while no symptoms are present at rest. Furthermore, stress testing can also be used to determine cardiac reserve in patients with valvular and myocardial disease. Deterioration of left ventricular performance during the test suggests a decline in cardiac reserve that could have therapeutic and prognostic implications.  
The induced cardiac stress is most widely used to compare the coronary circulation during exercise with the circulation in rest. An imbalance between myocardial oxygen supply and demand due to coronary disease can be revealed as a result of the increased oxygen demand during stress conditions. By this means stress testing can reveal myocardial ischemia during exercise, while no symptoms are present at rest. Furthermore, stress testing can also be used to determine cardiac reserve in patients with valvular and myocardial disease. Deterioration of left ventricular performance during the test suggests a decline in cardiac reserve that could have therapeutic and prognostic implications.  


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