CPVT: Difference between revisions

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''Supervisor: Arthur A.M. Wilde''
''Supervisor: Arthur A.M. Wilde''


'''Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)''' refers to a hereditary disease that is associated with exercise (or adrenergic) induced ventricular arrhythmias and/or cardiac syncope and carries an increased risk of sudden cardiac death.<cite>tachycardia</cite>
'''Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)''' refers to a hereditary disease that is associated with exercise (or adrenergic) induced ventricular arrhythmias and/or cardiac syncope and carries an increased risk of sudden cardiac death.




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*The resting ECG is normal and the heart is structurally normal.
*The resting ECG is normal and the heart is structurally normal.
*It is an inheritable cardiac arrhythmia syndrome<cite>arrhythm</cite> with an autosomal dominant (RyR2) or recessive (CASQ2) inheritance.
*It is an inheritable cardiac arrhythmia syndrome<cite>arrhythm</cite> with an autosomal dominant (RyR2) or recessive (CASQ2) inheritance.
*The arrhythmias typically occur in children and adolescents.
*The arrhythmias typically occur in children<cite>tachycardia</cite> and adolescents.
*The mortality rate is approximately 31% by the age of 30 years, if untreated.
*The mortality rate is approximately 31% by the age of 30 years, if untreated.
*The prevalence is estimated to be 1:10.000 in Europe.  
*The prevalence is estimated to be 1:10.000 in Europe.  
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#Werf pmid=21616285
#Werf pmid=21616285
#Wilde pmid=18463378
#Wilde pmid=18463378
#flecainide pmid=20851823
#Werf2 pmid=20851823
#Priori pmid=12093772
#Priori pmid=12093772
#ryanodine pmid=22787013
#ryanodine pmid=22787013
</biblio>''
</biblio>''