Chronic Coronary Disease: Difference between revisions

Chronic Coronary Disease (view source)

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-[[File:Endo_dysfunction_Athero.png|thumb|Different stages of atherosclerosis]]Even though chronic coronary disease mortality rates have declined since 1970 it is still the leading cause of death in many western countries and in an increasing number of non western countries.
+== Introduction ==
+Even though chronic coronary disease mortality rates have declined since 1970 it is still the leading cause of death in many western countries and in an increasing number of non western countries. PMID 20177011
-The cause of the reduction in mortality rates is mainly due to rapid recognition at special cardiac care units and the possibility of early intervention.
-But because survivors of a myocardial infarction still face a substantial risk of further cardiovascular events and a stitch in time saves nine, recognizing and reducing of risk factors is very important.
-The following risk factors for chronic coronary disease are modifiable and should be tackled.
+The cause of the reduction in mortality rates is mainly due to rapid recognition at special cardiac care units and the possibility of early intervention.  PMID 11004141, PMID 11182101
-Cigarette smoking damages the endothelium of the blood vessels making it easy for the cholesterol to adhere. Smoking is therefore a leading preventable cause of coronary disease. All patients who smoke should be counselled to give up smoking. Nicotine replacement therapy and behavioural therapy can help.
-Hypertension is like smoking disadvantageous for the endothelium of the blood vessels and so hypertension contributes to the progression of atherosclerosis. Hypertension is defined as a systolic pressure >140 mmHg and/or diastolic pressure >90 mmHg. Patients with hypertension should be first treated with non pharmacologic therapies, including salt restriction, weight reduction in overweight/obese patients, and avoidance of excess alcohol intake. Antihypertensive drugs are indicated in patients with persistent hypertension despite non pharmacologic therapy. Most patients will require multiple antihypertensive drug therapies.
-Cholesterol is the felon in the atherosclerosis tale and therefore cholesterol levels in the blood should be optimal, meaning low LDL levels and high HDL levels. This can be achieved by using statins.
+But because survivors of a myocardial infarction still face a substantial risk of further cardiovascular events recognizing and reducing of risk factors is very important.
-Exercise lowers morbidity and mortality from coronary disease.
-Obesity increases several risk factors for coronary heart disease, including hypertension, high cholesterol and insulin resistance as well as diabetes. Data show a linear relationship of higher body weight with morbidity and mortality from coronary disease. All patients who are willing, ready and able to lose weight should receive information about behaviour modification, diet, and increased physical activity.
+The following risk factors for chronic coronary disease are modifiable and should be tackled. PMID 15364185
-A healthy diet results in a significantly lower risk of coronary disease. A healthy diet consists of high intake of fruit and vegetables, high fiber intake, a low glycemic index and load, unsaturated fat rather than saturated fat, a limited intake of red or processed meat and intake of omega 3 fatty acids.
+== Risk Factors ==
+=== Cigarette Smoking ===
+Cigarette smoking damages the endothelium of the blood vessels potentially facilitating cholesterol adherence. Smoking is a reversible and therefore a leading preventable cause of coronary disease.  All patients who smoke should be counselled to give up smoking. Nicotine replacement therapy and behavioural therapy can assist . [ OR 2.87 for current vs never, PAR 35.7% for current and former vs never.]
+=== Hypertension  ===
+Hypertension is defined as a systolic pressure >140 mmHg and/or diastolic pressure >90 mmHg. Patients with hypertension should be first treated with non pharmacologic therapies, including salt restriction, weight reduction in overweight/obese patients, and avoidance of excess alcohol intake. Antihypertensive drugs are indicated in patients with persistent hypertension despite non pharmacologic therapy. Most patients will require multiple antihypertensive drug therapies. [ OR 1.91, PAR 17.9%]
-Several studies have shown that people who have a high intake of fruit and vegetables have a reduce risk coronary disease. It is possible that this is due to specific compounds in vegetables and fruits, or because people who eat more vegetables and fruits tend to eat less meat and saturated fat.
+=== Cholesterol ===
+Cholesterol is the felon in the atherosclerosis tale and therefore cholesterol levels in the blood should be optimal, meaning low LDL levels and high HDL levels. This can be achieved by the use of lipid lowering therapy which include statins. [ OR 3.25 for top vs lowest quintile, PAR 49.2% for top four quintiles vs lowest quintile]
-In diabetes mellitus tight glycemic control is important to protect against many vascular complications, including coronary disease.
+=== Obesity ===
-A small amount of alcohol results in a lower risk of morbidity and mortality from coronary disease.
+Obesity is associated with several risk factors for coronary heart disease, including hypertension, high cholesterol and insulin resistance as well as diabetes. Data show a relationship of higher body weight with morbidity and mortality from coronary disease. All patients who are willing, ready and able to lose weight should receive information about behaviour modification, diet, and increased physical activity. [OR 1.12 for top vs lowest tertile and 1.62 for middle vs lowest tertile, PAR 20.1% for top two tertiles vs lowest tertile]
-===Screening===
+== Prevention ==
-Because extensive coronary disease can exist with minimal or no symptoms screening for coronary disease has been suggested. Although screening results in indentifying patients at increased risk there is lack of evidence that screening actually improves outcome.
+=== Exercise ===
+Exercise lowers morbidity and mortality from coronary disease. [ OR 0.86, PAR 12.2%]
-===References===
+=== Healthy Diet ===
+A healthy diet potentially results in a lower risk of coronary disease. A healthy diet consists of high intake of fruit and vegetables, high fiber intake, a low glycemic index and load, unsaturated fat rather than saturated fat, a limited intake of red or processed meat and intake of omega 3 fatty acids. [OR 0.70, PAR 13.7% for lack of daily consumption of fruits and vegetables]
+Several studies have shown that people who have a high intake of fruit and vegetables have reduced risk coronary disease. It is possible that this is due to specific compounds in vegetables and fruits, or because people who eat more vegetables and fruits tend to eat less meat and saturated fat.
+In '''diabetes mellitus''' tight glycemic control is important to protect against many vascular complications, including coronary disease. [OR 2.37, PAR 9.9%]
+A small amount of '''alcohol''' results in a lower risk of morbidity and mortality from coronary disease. [OR 0.91, PAR 6.7%]
+== Screening ==
+Because extensive coronary disease can exist with minimal or no symptoms, screening for coronary disease has been suggested. Although screening results in indentifying patients at increased risk there is lack of evidence that screening actually improves outcome. PMID 12392846.
+[[File:Mortality_risk_for_people_with_heart_disease_and_type_2_diabetes.png|center]]